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Moskowitz, Ivan
One or more keywords matched the following properties of Moskowitz, Ivan
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overview The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).
One or more keywords matched the following items that are connected to Moskowitz, Ivan
Item TypeName
Concept Actins
Concept Action Potentials
Concept Age Factors
Concept Adenosine
Concept Antigens, Neoplasm
Concept Aortic Coarctation
Concept Aortic Valve Stenosis
Concept Arteries
Concept Arrhythmias, Cardiac
Concept Alleles
Concept Cardiomyopathy, Hypertrophic
Concept Animals
Concept Animals, Newborn
Concept Anti-Arrhythmia Agents
Concept Anal Canal
Concept Aortic Valve
Concept Cleft Lip
Concept Base Sequence
Concept Cations, Divalent
Concept Cell Movement
Concept Cell Nucleus
Concept Atrial Fibrillation
Concept Atrioventricular Node
Concept Chimera
Concept Bacterial Proteins
Concept Binding Sites
Concept Blastomeres
Concept Biopsy
Concept Bundle of His
Concept Embryonic Induction
Concept Bradycardia
Concept Chromosomes, Human, Pair 1
Concept Cardiomyopathy, Dilated
Concept Cell Transformation, Neoplastic
Concept Chromosome Deletion
Concept Cleft Palate
Concept Coronary Artery Disease
Concept Contractile Proteins
Concept DNA-Binding Proteins
Concept Cysteine Endopeptidases
Concept Immunosuppressive Agents
Concept DNA, Bacterial
Concept Down Syndrome
Concept Cell Fusion
Concept Echocardiography
Concept Ductus Arteriosus, Patent
Concept Cardiomegaly
Concept Heart Septum
Concept Heart Valves
Concept Lac Operon
Concept Electrophysiology
Concept Esophagus
Concept Cilia
Concept Eye Proteins
Concept DNA, Superhelical
Concept Infant, Newborn
Concept Electrocardiography
Concept Mice, Inbred C3H
Concept Multienzyme Complexes
Concept Atrial Natriuretic Factor
Concept Glycogen Storage Disease
Concept Genes, Lethal
Concept Fibroblast Growth Factors
Concept Genetic Complementation Test
Concept DNA (Cytosine-5-)-Methyltransferases
Concept Heart
Concept Heart Diseases
Concept Heart Failure
Concept Heart Septal Defects, Atrial
Concept Heart Ventricles
Concept Embryo, Mammalian
Concept Endocardium
Concept Escherichia coli
Concept Fluorescent Antibody Technique
Concept Heart Atria
Concept Membrane Glycoproteins
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Mice, Transgenic
Concept Nerve Tissue Proteins
Concept Molecular Sequence Data
Concept Purpura, Thrombocytopenic
Concept Mesoderm
Concept Mice, Inbred C57BL
Concept Repetitive Sequences, Nucleic Acid
Concept Myocardial Contraction
Concept Nucleic Acid Conformation
Concept Mediastinal Neoplasms
Concept Embryonic and Fetal Development
Concept Fibrosis
Concept Pre-Excitation Syndromes
Concept Procainamide
Concept Tetralogy of Fallot
Concept Poliomyelitis
Concept Protein Binding
Concept Proteins
Concept Heart Defects, Congenital
Concept Heart Septal Defects, Ventricular
Concept Receptors, Cell Surface
Concept Repressor Proteins
Concept Risk Factors
Concept Wolff-Parkinson-White Syndrome
Concept Xenopus
Concept Cohort Studies
Concept Regulatory Sequences, Nucleic Acid
Concept Sarcomeres
Concept Sinoatrial Node
Concept Sodium
Concept Risk
Concept Humans
Concept Single-Blind Method
Concept Spine
Concept Transcription, Genetic
Concept Truncus Arteriosus
Concept United States
Concept Trisomy
Concept Caenorhabditis elegans
Concept Tamoxifen
Concept Xenopus laevis
Concept Sodium Channels
Concept Trans-Activators
Concept Helminth Proteins
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Protein Subunits
Concept Chromosomes, Artificial, Bacterial
Concept Models, Animal
Concept Ventricular Fibrillation
Concept Transforming Growth Factor beta
Concept Extracellular Matrix Proteins
Concept Vacuolar Proton-Translocating ATPases
Concept Giant Cells
Concept Mutagenesis
Concept Antigens, CD
Concept Lymphoma
Concept Mortality
Concept Gene Expression
Concept Chromosomes, Mammalian
Concept Myocardium
Concept Lower Extremity Deformities, Congenital
Concept Connexins
Concept Limb Deformities, Congenital
Concept Genes, Reporter
Concept Cardiomyopathies
Concept Myocarditis
Concept RNA-Binding Proteins
Concept Point Mutation
Concept Hypertrophy, Left Ventricular
Concept Connexin 43
Concept Sequence Deletion
Concept Mice, Knockout
Concept Cell Proliferation
Concept Ventricular Dysfunction
Concept Disease Progression
Concept Basic-Leucine Zipper Transcription Factors
Concept Transgenes
Concept Chemokines, CC
Concept Protein Transport
Concept Cardiomyopathy, Hypertrophic, Familial
Concept Calcium Signaling
Concept Mutation, Missense
Concept Xenopus Proteins
Concept Myosin Heavy Chains
Concept In Situ Hybridization, Fluorescence
Concept Fatal Outcome
Concept Single-Cell Analysis
Concept Peripheral Blood Stem Cell Transplantation
Concept Intercellular Signaling Peptides and Proteins
Concept Embryonic Development
Concept Chromatin Assembly and Disassembly
Concept Smad4 Protein
Concept Genomic Imprinting
Concept Response Elements
Concept Cell Cycle Proteins
Concept Bone Morphogenetic Proteins
Concept Small Ubiquitin-Related Modifier Proteins
Concept Myocytes, Cardiac
Concept Retinal Dehydrogenase
Concept Platelet Count
Concept SUMO-1 Protein
Concept Progeria
Concept Animals, Genetically Modified
Concept Postoperative Complications
Concept Promoter Regions, Genetic
Concept Mice
Concept Receptors, Notch
Concept Hedgehog Proteins
Concept Sarcoplasmic Reticulum
Concept Laser Therapy
Concept Brugada Syndrome
Concept RNA, Messenger
Concept Lamin Type A
Concept Mechanotransduction, Cellular
Concept HEK293 Cells
Concept E2F3 Transcription Factor
Concept GATA4 Transcription Factor
Concept GATA6 Transcription Factor
Concept Wnt2 Protein
Concept Kruppel-Like Transcription Factors
Concept Inhibitor of Differentiation Protein 2
Concept Adaptor Proteins, Signal Transducing
Concept Insulin-Secreting Cells
Concept Regulatory Elements, Transcriptional
Concept Chemokine CCL4
Concept Zebrafish
Concept Fibroblast Growth Factor 4
Concept Fibroblast Growth Factor 8
Concept Heart Transplantation
Concept Axonemal Dyneins
Concept Cyclosporine
Concept Mice, 129 Strain
Concept Death, Sudden, Cardiac
Concept Ventricular Outflow Obstruction
Concept Reproducibility of Results
Concept Genes, Helminth
Concept Survival Rate
Concept DNA Methylation
Concept Integrases
Concept Troponin T
Concept Stroke
Concept T-Box Domain Proteins
Concept Gene Silencing
Concept Homeodomain Proteins
Concept Cardiac Myosins
Concept Ubiquitin
Concept Ventricular Dysfunction, Left
Concept Cell Lineage
Concept Macrophage Inflammatory Proteins
Concept Body Patterning
Concept Phosphatidylinositol 3-Kinases
Concept Caenorhabditis elegans Proteins
Concept Nuclear Matrix-Associated Proteins
Concept Electrophysiologic Techniques, Cardiac
Concept Tumor Suppressor Proteins
Concept Mutant Proteins
Concept Transcriptome
Concept Ventricular Septum
Concept Genome-Wide Association Study
Concept AMP-Activated Protein Kinases
Concept Haploinsufficiency
Concept Upper Extremity Deformities, Congenital
Concept Organogenesis
Concept Intracellular Signaling Peptides and Proteins
Concept Forkhead Transcription Factors
Concept Atrial Septum
Concept Gastrulation
Concept National Heart, Lung, and Blood Institute (U.S.)
Concept Induced Pluripotent Stem Cells
Concept Sumoylation
Concept Calcium
Concept Calcium-Binding Proteins
Concept Carrier Proteins
Concept Cell Line
Concept Cells, Cultured
Concept Brain Ischemia
Concept Chromatin
Concept Cytoskeletal Proteins
Concept Disease Models, Animal
Concept Endothelium
Concept Enhancer Elements, Genetic
Concept Epidermis
Concept Ethylnitrosourea
Concept Genetic Testing
Concept Heart Conduction System
Concept Heart Rate
Concept Heart Septal Defects
Concept Heart Valve Diseases
Concept Hydrocephalus
Concept Hysteria
Concept Intercellular Junctions
Concept Mice, Mutant Strains
Concept Models, Biological
Concept Salamandridae
Concept Staining and Labeling
Concept Translocation, Genetic
Concept Mutagenesis, Insertional
Concept Receptors, Platelet-Derived Growth Factor
Concept Regulon
Concept Computational Biology
Concept Genetic Predisposition to Disease
Concept Polymorphism, Single Nucleotide
Concept Genomics
Concept Potassium Channels, Voltage-Gated
Concept Databases, Nucleic Acid
Concept Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept Genetic Loci
Concept Cytoplasmic Dyneins
Academic Article lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.
Academic Article Comparison of two murine models of familial hypertrophic cardiomyopathy.
Academic Article Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Academic Article Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Academic Article Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Academic Article A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Academic Article Characterization of sinoatrial node in four conduction system marker mice.
Academic Article Complex genomic rearrangement in CCS-LacZ transgenic mice.
Academic Article The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Academic Article Genome-wide identification of mouse congenital heart disease loci.
Academic Article A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.
Academic Article Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.
Academic Article Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
Academic Article TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Academic Article E2F3 plays an essential role in cardiac development and function.
Academic Article Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article Complex interactions between genes controlling trafficking in primary cilia.
Academic Article Defective sumoylation pathway directs congenital heart disease.
Academic Article Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.
Academic Article Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Academic Article Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
Academic Article sonic hedgehog is required in pulmonary endoderm for atrial septation.
Academic Article DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.
Academic Article The emerging genetic landscape underlying cardiac conduction system function.
Academic Article Alignment of recombination sites in Hin-mediated site-specific DNA recombination.
Academic Article Hysteria in poliomyelitis.
Academic Article Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.
Academic Article Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Academic Article Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.
Academic Article Tetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship.
Academic Article Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Academic Article Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
Academic Article Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Academic Article The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
Academic Article Many ways to break a heart.
Academic Article The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
Academic Article Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Academic Article Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Academic Article TBX5: A Key Regulator of Heart Development.
Academic Article Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.
Academic Article Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
Academic Article Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.
Academic Article Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Academic Article A promoter interaction map for cardiovascular disease genetics.
Academic Article Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.
Academic Article A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.
Academic Article Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Academic Article Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.
Academic Article A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Academic Article Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
Academic Article Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.
Academic Article Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
Academic Article Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Academic Article ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Academic Article Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Academic Article Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.
Academic Article Chamber-specific transcriptional responses in atrial fibrillation.
Academic Article Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article Control of cardiomyocyte differentiation timing by intercellular signaling pathways.
Academic Article Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article Identification of direct transcriptional targets of NFATC2 that promote ß cell proliferation.
Academic Article Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Academic Article Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Academic Article Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.
Academic Article Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Academic Article Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
Academic Article Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Concept N-Myc Proto-Oncogene Protein
Concept Zinc Finger Protein GLI1
Concept Smoothened Receptor
Concept Homeobox Protein Nkx-2.5
Concept Zinc Finger Protein Gli3
Concept Receptor, Notch4
Concept NAV1.5 Voltage-Gated Sodium Channel
Concept NAV1.8 Voltage-Gated Sodium Channel
Concept Zonula Occludens-1 Protein
Concept Filamins
Concept Atrial Remodeling
Grant Gene Regulatory Networks for Cardiac Morphogenesis
Grant Genetic and Molecular Analysis of Congenital Heart Disease
Grant Functional Assays to Screen Genomic Hits
Grant Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome
Grant Functional Assays to Screen Genomic Hits
Grant Etiology of Congenital Heart Disease in Down Syndrome
Academic Article Tbx5 maintains atrial identity by regulating an atrial enhancer network.
Academic Article ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Academic Article Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.
Academic Article The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture.
Academic Article An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
Academic Article A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Academic Article Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
Search Criteria
  • Homeobox
  • Protein
  • Nkx
  • 2
  • 5